Publications. A selection from Stockholm University publication database. Article Seed traits are pleiotropically regulated by the flowering time

A. Controls multiple traits in an individual. B. Controls a trait only in combination with another gene. Hard. Answer.

A pleiotropic gene. A. Controls multiple traits in an individual. B. Controls a trait only in combination with another gene. Hard. Answer. Correct option is . A. Controls multiple traits in an individual.

Genomic Selection of Quantitative Traits in Norway spruce marker density, number of QTL, heritability, pleiotropic and dominance effect on the efficiency of GS

For example, the symptoms associated with sickle-cell disease are due to pleiotropic effects. Individuals with sickle-cell disease are homozygous for the mutant allele, resulting in sickle-shaped red blood cells. The pleiotropic gene encodes a protein into chains and makes fibrils that provide flexibility and strength to the body’s connective tissues. In Marfan syndrome, it minimizes the amount of metabolism protein formed by the body and results in lesser fibrils.

These results indicate that antagonistic pleiotropy is the dominant mechanism in exist as evolutionary trade-offs may impose collateral cost to obtain new traits.

The number of traits affected by a pleiotropic locus varied, from 11 loci affecting single traits to loci with effects on as many as 30 traits. We expect pleiotropic loci that affect a large number of traits to also affect one or both of the body-weight traits (week-10 body weight or weight at necropsy), as these loci may affect overall body size. Pleiotropy is the phenomenon where one gene controls for more than one phenotypic trait in an organism.

In Mendelian inheritance, a single gene is involved in determining a single trait. Pleiotropy means that a single gene affects two or more characters. In the context of life history evolution, pleiotropy means that a single gene affects the fitness of the organism at two or more ages. It is convenient to categorize the combinations of age-specific pleiotropic effects as shown in Table 1. Abstract Genome-wide association studies have identified many variants that each affects multiple traits, particularly across autoimmune diseases, cancers and neuropsychiatric disorders, suggesting In pleiotropism, a single gene affects a number of phenotypic traits in the same organism. These pleiotropic effects often seem to be unrelated to each other.
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SNP pleiotropic status was associated with gene location (p = 0.024; pleiotropic SNPs more often exonic [14.5% versus 4.9% for nonpleiotropic Pleiotropism is a central term in developmental genetics.In pleiotropism, a single gene affects a number of phenotypic traits in the same organism..

QTL in an outbred population. The method is based on results from single-trait analyses for different traits.
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The method is based on results from single-trait analyses for different traits. 14 Jul 2019 Both pleiotropic connectivity and mutational correlations can restrict the divergence of traits under directional selection, but it is unknown which Then, to identify the genetic factors responsible for seed protein content and yield variation, we searched for quantitative trait loci (QTL) for seed traits and for 9 May 2019 Pleiotropy is defined as one gene influencing more than one trait.

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These pleiotropic effects often seem to be unrelated to each other. Skeletal and glycemic traits have shared etiology, but the underlying genetic factors remain largely unknown. To identify genetic loci that may have pleiotropic effects, we studied Genome-wide association studies (GWASs) for bone mineral density and glycemic traits and identified a bivariate risk locus at 3q21. Polygenic traits are traits that are expressed as the combined expression of multiple genes.

To determine the mechanism of the pleiotropic effects of GmPDAT on seed oil-related traits, we genotyped 171 orthogonal and 227 reciprocal RILs from the cross between the landrace LSZZH and the bred line NN493-1 for 11 846 SNPs, and measured phenotypic values of five triacylglycerols (TAGs) in seeds at 45 DAF (Supplementary Fig. S9, Supplementary Table S15).

/ Chami, Nathalie; Chen, Ming Huei; Slater, Andrew J.; Eicher, John D.; These candidate quantitative genes were then assessed for potential pleiotropic effects on bone tissue and fecundity traits.

When studying a polygenic trait, the ________ are often difficult to determine. 2018-10-25 2017-04-28 2021-02-08 2011-11-11 As the appreciation of pleiotropic effects has gained traction in the scientific community, cross-disorder analyses of several related traits have been increasingly carried out to disentangle shared and disease-specific genetic determinants [27–30]. Alternatively, even if the pleiotropic gene responds to the same cue in the same manner, it may regulate its downstream partner differently for different traits; for instance, high temperature may upregulate the pleiotropic gene at all life stages, but that gene may upregulate its partner at one life stage but downregulate that same partner at a different stage.